COVID Testing Kits
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ABclonal Technology SARS-CoV-2 3CLpro Rabbit mAb
SARS-CoV-2 is an enveloped positive-sense single-stranded RNA virus that causes COVID-19 Its genome encodes structural nonstructural and accessory proteins The largest gene ORF1ab encodes polyproteins PP1a and PP1ab produced via -1 ribosomal frameshifting These are cleaved into 16 nonstructural proteins (NSP1 NSP16) essential for viral replication transcription and immune evasion Key NSPs include NSP3 (papain-like protease) NSP5 (3CL protease) NSP12 (RNA-dependent RNA polymerase) NSP13 (helicase) NSP15 (endoRNAse) and NSP16 (2 -O-methyltransferase) These proteins control viral replication gene expression and host suppression RdRp (NSP12) is a major antiviral target
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